Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50022831'
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKon:  25M-1s-1Assay Description:Dissociation constant at(Koff) Tyr-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKoff:  1.20E+7s-1Assay Description:Association constant (Kon) at Phe-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKd:  1.60E+3nMpH: 6.0Assay Description:Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKd:  3.90E+3nMpH: 6.0Assay Description:Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKoff:  6.80E+6s-1Assay Description:Association constant(Kon) at Tyr-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKon:  35M-1s-1Assay Description:Dissociation constant(Koff) at Phe-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  44nMAssay Description:Inhibition constant for Phe31-dihydrofolate reductase (DHFR)-NADPH-Compound complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  57nMAssay Description:Inhibition constant for Tyr31-dihydrofolate reductase (DHFR)-NADPH-Compound complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition constant for Val31-dihydrofolate reductase (DHFR)-NADPH-Compound complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed