Found 5 Enz. Inhib. hit(s) with Target = 'Dihydroorotate dehydrogenase (quinone), mitochondrial' and Ligand = 'BDBM50365225' TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Board Of Regents, The University Of Texas System
US Patent
Board Of Regents, The University Of Texas System
US Patent
Affinity DataIC50: 35nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University Of Texas At Dallas
Curated by ChEMBL
University Of Texas At Dallas
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University Of Texas At Dallas
Curated by ChEMBL
University Of Texas At Dallas
Curated by ChEMBL
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Texas At Dallas
Curated by ChEMBL
University Of Texas At Dallas
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Texas At Dallas
Curated by ChEMBL
University Of Texas At Dallas
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assayMore data for this Ligand-Target Pair
