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Report error Found 14 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1' and Ligand = 'BDBM50355497'
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataKd:  99nMAssay Description:Binding constant for MEK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 9nMAssay Description:Inhibition of MEK1 (unknown origin) using Ser/Thr 03 peptide substrate after 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 31nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 60nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 80nMAssay Description:Inhibition of MEK1 (unknown origin) after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu-ADR matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 5.84E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 7.76E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)