Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with Target = 'Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha' and Ligand = 'BDBM50481799'
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 200nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 500nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 900nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50481799(CHEMBL1083495)
Show SMILES CC(=O)C1=CC[C@H]2[C@]3(C)CC[C@H]4C(C)(C)CCC[C@]4(CO)[C@H]3CC(=O)[C@]2(C)[C@H]1C=O
Show InChI InChI=1S/C26H38O4/c1-16(29)17-7-8-20-24(4)12-9-19-23(2,3)10-6-11-26(19,15-28)21(24)13-22(30)25(20,5)18(17)14-27/h7,14,18-21,28H,6,8-13,15H2,1-5H3/t18-,19-,20-,21-,24-,25+,26+/m0/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid