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Found 15 Enz. Inhib. hit(s) with Target = 'Endothelin receptor type B' and Ligand = 'BDBM50061101'
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataKi:  80nMAssay Description:Inhibitory activity against human endothelin B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataKi:  102nMMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataKi:  134nMMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataKi:  340nMAssay Description:Ability of the compound to displace endothelin ([125I]-ET-1) from human Endothelin B receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  95nMAssay Description:Binding affinity to human ETB receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(RAT)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  95nMAssay Description:Displacement of [125I]ET-1 from rat ETB receptor after 1 hr by Lowry methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  150nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  150nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  150nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  202nMAssay Description:Antagonist activity at ET-B receptor (unknown origin)More data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  202nMAssay Description:Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  202nMAssay Description:Displacement of 125I-ET1 from human placenta ETB receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  202nMAssay Description:Displacement of 125I-ET1 from human placenta ETB receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibitory concentration required against [125I]-ET-1 binding to membranes of CHO cells expressing human ETB receptorMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at ETB receptor (unknown origin) assessed as effect on G protein-mediated smooth muscle contractionMore data for this Ligand-Target Pair