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Found 8 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM17289'
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  29nM EC50:  166nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  96nMAssay Description:Displacement of [3H]17beta-estradiol from human ERalpha expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  210nMAssay Description:Binding affinity towards estrogen receptor alpha by [3H]17-beta-estradiol displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  480nM EC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at full length human ERalpha receptor assessed as transcriptional activity incubated for 22 to 24 hrs by cell based luciferase repor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataEC50:  7nMAssay Description:Activity at human recombinant ERalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataEC50: >50nMAssay Description:Antagonist activity at full length human ERalpha receptor assessed as inhibition of estradiol-induced activation incubated for 22 to 24 hrs by cell b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataEC50:  120nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed