Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E' and Ligand = 'BDBM50316303'
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  45nMAssay Description:Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  49nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  70nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed