Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E-binding protein 1' and Ligand = 'BDBM544953'
TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM544953(US11286268, Compound 439a)
Show SMILES CN(C)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)F
Show InChI InChI=1S/C30H24ClF2N5O4S/c1-14-9-18(27-25(35-14)21(13-43-27)30(40)41)17-10-16(31)5-6-23(17)42-8-7-38-15(2)36-22-11-19(28(32)33)26(37(3)4)20(12-34)24(22)29(38)39/h5-6,9-11,13,28H,7-8H2,1-4H3,(H,40,41)
Affinity DataIC50: 2.87nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid