Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E-binding protein 1' and Ligand = 'BDBM545327'
TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM545327(US11286268, Compound 815)
Show SMILES CN1CCN(CC1(C)C)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3ccnc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C32H30ClN7O4S/c1-18-37-24-15-36-29(39-10-9-38(4)32(2,3)17-39)22(14-34)26(24)30(41)40(18)11-12-44-25-6-5-19(33)13-21(25)20-7-8-35-27-23(31(42)43)16-45-28(20)27/h5-8,13,15-16H,9-12,17H2,1-4H3,(H,42,43)
Affinity DataIC50: 3.31nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid