Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E-binding protein 1' and Ligand = 'BDBM545473'
TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM545473(US11286268, Compound 964)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4nc(C)ncc4F)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H21ClF4N6O4S/c1-14-8-19(30-28(41-14)21(13-49-30)32(46)47)18-9-17(34)4-5-25(18)48-7-6-44-16(3)43-24-10-22(33(36,37)38)26(20(11-39)27(24)31(44)45)29-23(35)12-40-15(2)42-29/h4-5,8-10,12-13H,6-7H2,1-3H3,(H,46,47)
Affinity DataIC50: 3.32nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid