Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E-binding protein 1' and Ligand = 'BDBM545475'
TargetEukaryotic translation initiation factor 4E-binding protein 1(Homo sapiens (Human))
eFFECTOR Therapeutics, Inc.

US Patent
LigandPNGBDBM545475(US11286268, Compound 966)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ncc(F)cn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H19ClF4N6O4S/c1-14-7-19(28-27(41-14)21(13-48-28)31(45)46)18-8-16(33)3-4-24(18)47-6-5-43-15(2)42-23-9-22(32(35,36)37)25(20(10-38)26(23)30(43)44)29-39-11-17(34)12-40-29/h3-4,7-9,11-13H,5-6H2,1-2H3,(H,45,46)
Affinity DataIC50: 3.58nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid