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Found 10 Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM249396'
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  320nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  575nMAssay Description:The experimental procedure is briefly described as follows: the test compound was first dissolved in DMSO to prepare a stock solution, and then gradi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  575nMAssay Description:The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of human FGFR3 using Poly [E,Y] 4:1 substrate pre-incubated for 15 to 60 mins followed by ATP and [gamma33P]-ATP additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  2.00E+3nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  2.00E+3nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  2.00E+3nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 &#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM249396(US10537571, Compound 108 | US10562888, Compound 10...)
Affinity DataIC50:  2.00E+3nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...More data for this Ligand-Target Pair
In DepthDetails US Patent