Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM19191'
TargetGlucocorticoid receptor(Rat)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM19191((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM19191((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataEC50:  63nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

LigandPNGBDBM19191((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 8.40nM EC50:  2.90nMpH: 7.5 T: 2°CAssay Description:The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM19191((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 20nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
University of Tennessee

Curated by ChEMBL
LigandPNGBDBM19191((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...)
Affinity DataIC50: 40nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed