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Found 178 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 2' and Ligand = 'BDBM19149'
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  40nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  42nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  100nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant HDAC2 using acetyllysine tripeptide coupled with 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMT: 2°CAssay Description:Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human HDAC2 incubated for 30 mins by SpectraMax M2 microplate reader analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  13nMAssay Description:Inhibition of C-terminal 6XHis-tagged human recombinant full length HDAC2 (1 to 488 residues) expressed in baculovirus-infected Sf9 cells assessed as...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate by measuring fluorescence intensity incubated for 30 mins by micropla...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant full-length HDAC2 using fluorophore conjugated substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  17nMAssay Description:Inhibition of HDAC2 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HDAC2 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence based micr...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HDAC2 (unknown origin) using Boc-Lys-(acetyl)-AMC as substrate incubated for 0.5 hr and measured after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  22nMAssay Description:Inhibition of HDAC2 (unknown origin) using trypsin and Ac-peptide as substratesMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant HDAC2 using fluor de Lys as substrate by fluorometric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant human full length C-terminal His tagged HDAC2 (1 to 488 residues) expressed in baculovirus-infected Sf9 insect cells using ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  26nMAssay Description:Inhibition of HDAC2 (unknown origin) using Ac-peptide as a substrate pretreated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  27nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  28nMAssay Description:Inhibition of C-terminal His-tagged full length human HDAC2 expressed in baculovirus expression system using Ac-peptide substrate incubated for 15 mi...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  28nMAssay Description:Inhibition of HDAC2 (unknown origin) by colorimetric methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in sf9 insect cells using Ac-peptide-AMC as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  31nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substra...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human full-length recombinant HDAC2 preincubated for 5 mins followed by HDAC substrate addition and further incubated for 45 mins by fl...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  35nMAssay Description:Inhibition of HDAC2 (unknown origin) using biotinylated histone H3 KAc peptide (1 to 21 residues) as substrate by HTRF assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in baculovirus expression system using Ac-peptide-AMC as substrate preincubated for 15 mi...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in baculovirus expression system using Ac-peptide-AMC as substrate preincubated for 15 mi...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  36nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  40nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubated for 15 m...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  66nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  66nMAssay Description:Inhibition of recombinant human HDAC2 using Fluor-de-Lys as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC2 (1 to end residues) expressed in sf9 insect cells using Boc-Lys(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human recombinant HDAC2 preincubated for 24 hrs followed by 1 hr reaction with substrate by protease coupled end-point assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  73nMAssay Description:Inhibition of Histone deacetylase 2 (HDAC2) activity of HeLa nuclear extractsMore data for this Ligand-Target Pair
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