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Found 14 Enz. Inhib. hit(s) with Target = 'Integrase' and Ligand = 'BDBM50240448'
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataKi:  4.40E+3nMAssay Description:Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataKi:  3.80E+4nMAssay Description:Competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-reciprocal ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase N155H mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase E92Q mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase E138K mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of HIV-1 integrase G140S mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50:  1.50E+5nMAssay Description:Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Lomonosov Moscow State University

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataIC50: >5.00E+5nMAssay Description:Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed