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Found 4 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50187649'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50187649((S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,...)
Affinity DataEC50:  170nMAssay Description:Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50187649((S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,...)
Affinity DataEC50:  157nMAssay Description:Positive allosteric modulation of human mGluR5 stably expressed in HEK293 cells assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50187649((S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,...)
Affinity DataEC50:  199nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50187649((S)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-[1,2,...)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed