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Report error Found 5 Enz. Inhib. hit(s) with Target = 'Mitogen-activated pr...
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  1nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  11nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKon:  0.000120M-1s-1 Koff:  1.13E+5s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKon:  0.000120M-1s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed