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Found 3 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 1' and Ligand = 'BDBM519706'
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM519706(US11142525, Example 107)
Affinity DataKi:  0.0400nMAssay Description:HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay (MSA). The reactions were conducted in 50 μL volumes in 96-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM519706(US11142525, Example 107)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition constant in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM519706(US11142525, Example 107)
Affinity DataIC50:  22nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as inhibition of SLP76 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed