Report error Found 28 Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM21641'
Affinity DataKi: 4nM ΔG°: -49.9kJ/molepH: 7.4 T: 37°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 4.70nMAssay Description:Compound was evaluated for inhibition of recombinant human neprilysin(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Binding affinity towards enkephalinase (metalloendopeptidase, E.C.3.4.24.11) of rat kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration was evaluated by Inhibiting 50% of Neutral endopeptidase enzyme (NEP) activity using 20 nM [3H]-D-Ala2-Leu-enkephalin as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of enkephalinase purified from rat kidney.More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP 24.11) from rat kidney cortex membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Tested in vitro for the inhibition against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibition of neutral endopeptidase from rat kidney.More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMT: 25°CAssay Description:Enzyme inhibition assay using neutrol endopeptiase EC 3.4.24.11 (NEP).More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:The compound was tested for its inhibitory activity against neutral endopeptidase (EC.3.4.24.111) in rat kidneyMore data for this Ligand-Target Pair
