Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-4/beta-2' and Ligand = 'BDBM50100717'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.00900nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes using [3H]epibatidine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of [3H]epibatidine binding to alpha4-beta2 nACh receptor from rat membranes from ref 16More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 18More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0260nMAssay Description:In vitro binding affinity towards (alpha-4)2(beta-2)3 neuronal nicotinic acetylcholine receptor in P2 membrane fractions of rat forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0310nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0640nMAssay Description:Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataKi:  0.0640nMAssay Description:Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50100717BDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | CHE...)
Affinity DataEC50:  3.63E+3nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed