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Found 5 Enz. Inhib. hit(s) with Target = 'Neutrophil elastase' and Ligand = 'BDBM211950'
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211950(US9290459, 30B | US9475779, C.2B | US9670166, 30B)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211950(US9290459, 30B | US9475779, C.2B | US9670166, 30B)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211950(US9290459, 30B | US9475779, C.2B | US9670166, 30B)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:The following buffers were used: Compound buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5; Assay buffer: 100 mM Tris, 500 mM NaCl, adjusted to p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211950(US9290459, 30B | US9475779, C.2B | US9670166, 30B)
Affinity DataIC50:  1.83E+3nMpH: 7.5 T: 2°CAssay Description:The following buffers were used: Compound buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5; Assay buffer: 100 mM Tris, 500 mM NaCl, adjusted to p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM211950(US9290459, 30B | US9475779, C.2B | US9670166, 30B)
Affinity DataEC50:  2nMpH: 7.5Assay Description:Various concentrations of the neutrophil elastase inhibitor are incubated with plasma. Subsequently, the enzyme activity is measured using the fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent