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Found 6 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM50192909'
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)
Affinity DataIC50:  2.00E+3nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)
Affinity DataIC50:  2.00E+3nMAssay Description:A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)
Affinity DataIC50:  3.00E+3nMAssay Description:A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)
Affinity DataIC50:  3.00E+3nMAssay Description:PI3 Kinase α, β, γ or δ activity was assayed using the PI3 Kinase HTRF® assay kit (catalogue No. 33-016) purchased from Millipore...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50192909(CHEMBL3921445 | US10329299, Compound 41 | US106752...)
Affinity DataIC50:  5.00E+3nMAssay Description:A compound's ability in selectively inhibiting PI3K-γ can be assessed using RAW264.7 macrophages. Briefly, serum-starved RAW264.7 cells are ...More data for this Ligand-Target Pair
In DepthDetails US Patent