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Found 5 Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50000829'
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibition of leukotriene B4 synthesis in human whole blood by inhibiting 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of 5-lipoxygenase from human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  83nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  330nMAssay Description:Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed