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Found 9 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2' and Ligand = 'BDBM50117913'
TargetPotassium voltage-gated channel subfamily H member 2(Cavia porcellus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  180nMAssay Description:Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp tech...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  400nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  560nMAssay Description:K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  562nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  562nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  562nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50117913((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed