Found 6 Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM119448' TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd
US Patent
Eisai R&D Management Co., Ltd
US Patent
Affinity DataKi: 8nMpH: 7.4Assay Description:The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd
US Patent
Eisai R&D Management Co., Ltd
US Patent
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd
US Patent
Eisai R&D Management Co., Ltd
US Patent
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eisai R&D Management Co., Ltd
US Patent
Eisai R&D Management Co., Ltd
US Patent
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human EP4 receptor overexpressed in HEK293 cells assessed as reduction in PGE2-mediated cAMP accumulation preincubated for 30 ...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Mus musculus (Mouse))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: 101nMAssay Description:Antagonist activity at mouse EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Mus musculus (Mouse))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: 181nMAssay Description:Antagonist activity at mouse EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
