Report error Found 186 Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' and Ligand = 'BDBM17638'
Affinity DataKd: 1.02E+3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 92nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition by colorimetric assa...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)More data for this Ligand-Target Pair
Affinity DataIC50: 6.40nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.More data for this Ligand-Target Pair
Affinity DataIC50: 6.40nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of ovine COX2 using arachidonic acid substrate incubated for 5 mins by colorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant COX2 after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In vivo ability to inhibit Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against human whole cells (CHO) Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of COX2 assessed as LPS-stimulated PGE2 production in human whole blood leukocyteMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EL...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant COX2 expressed in insect cells using arachidonic acid as substrate incubated for 1 min prior to substrate addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 10 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 72.5nMAssay Description:The inhibitory effects of candidate compounds on COX-1 and COX-2 were determined using COX inhibitor screening test kits, testing each compound's...More data for this Ligand-Target Pair
Affinity DataIC50: 72.5nMAssay Description:The inhibitory effects of candidate compounds on COX-1 and COX-2 were determined using COX inhibitor screening test kits, testing each compound's...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 min...More data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Inhibition of wild type mouse COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in CHO whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of wild type mouse COX2 by discontinuous radioactive TLC assayMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition concentration against Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:In vitro inhibitory concentration against rat Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:We evaluated the ability of test compounds to inhibit purified ovine COX-1 or murine COX-2 utilizing previously published protocols. [Uddin et al, Ca...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of ovine COX2More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Biochemical index for Prostaglandin G/H synthase 2 measured as, PGE-2 levels in lipopolysaccharide (LPS)-challenged human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibitory potency against cyclooxygenase-2 in human whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:In vivo ability to inhibit Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
