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Found 6 Enz. Inhib. hit(s) with Target = 'Proteinase-activated receptor 4' and Ligand = 'BDBM364565'
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at full-length human PAR4 expressed in HEK293 cells assessed as inhibition of AYPGKF-induced intracellular calcium mobilization p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PAR4 expressed in HEK293 cells assessed as Ala-(L-4-F-Phe)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-induced inhibition of calcium mobiliza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Affinity DataIC50:  14nMAssay Description:The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity at PAR4 in human washed platelets assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Affinity DataIC50:  940nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Affinity DataIC50:  2.60E+3nMAssay Description:Antagonist activity at PAR4 in human platelet-rich plasma assessed as inhibition of gamma-thrombin-induced platelet aggregation preincubated for 5 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed