Found 19 Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase' and Ligand = 'BDBM50195587'
Affinity DataKi: 0.0560nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Inhbitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
Affinity DataKi: 0.0579nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
Affinity DataKi: 0.860nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of human purine nucleoside phosphorylase; Initial rate.More data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity towards Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formationMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences
Curated by ChEMBL
Tokyo University Of Pharmacy And Life Sciences
Curated by ChEMBL
Affinity DataKi: 41nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inor...More data for this Ligand-Target Pair
Affinity DataKi: 72nMAssay Description:Inhibition of human PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human PNP activityMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human purine nucleoside phosphorylaseMore data for this Ligand-Target Pair
Affinity DataKd: 0.0560nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences
Curated by ChEMBL
Tokyo University Of Pharmacy And Life Sciences
Curated by ChEMBL
Affinity DataKd: 0.0230nMAssay Description:Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 0.0580nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair