Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1a' and Ligand = 'BDBM83922'
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataIC50: 800nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins by fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition of SARS-CoV 3CLpro expressed in Escherichia coli BL21 (DE3) using Dabcyl-KNSTLQSGLRKE-Edan as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataKi:  1.12E+4nMAssay Description:Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed