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Report error Found 18 Enz. Inhib. hit(s) with Target = 'Replicase polyprotei...
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataKi:  30nM IC50:  31nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataKi:  60nMAssay Description:Binding affinity to SARS CoV-2 3CL protease using dabcyl-KTSAVLQ/SGFRKME-edans as substrate incubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataKi:  94nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from rat liver.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 (BetaCoV/Wuhan/WIV04/2019) MPro expressed in Escherichia coli using FRET susbtrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS CoV-2 3CL protease using dabcyl-KTSAVLQ/SGFRKME-edans as substrate incubated for 30 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  33nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from rat liver.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  190nMAssay Description:Inhibition of SARS-CoV-2 3CL protease by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  460nMAssay Description:Inhibition of MBP tagged recombinant SARS-CoV-2 main protease using DABCYL-KTSAVLeu(13C6,15N)-Q as substrate incubated for 2 to 3 hrs by mass spectro...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  620nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  4.35E+3nMAssay Description:Inhibition of SARS CoV 3CL protease using dabcyl-KTSAVLQ/SGFRKME-edans as substrate incubated for 30 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50: >5.00E+4nMAssay Description:Covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50: >6.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University of Bonn

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataEC50:  9.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed