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Report error Found 4 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM423462'
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  3.18nMAssay Description:Mpro activity was measured according to the manufacturer's protocol (BPS Biosciences, cat #78042-2) in 384-well plates. The included recombinant un-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  60nMAssay Description:Inhibition of SARS-CoV-2 3CL protease by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataEC50:  1.40E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(SARS coronavirus Urbani)
Pfizer

WIPO
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataEC50:  1.40E+6nMAssay Description:Proteolytic activity of Coronavirus 3C protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS 3CI_pro FRET as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed