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Found 6 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM423465'
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423465(US11753373, Compound A-1-c | WO2006061714, P38.8 |...)
Affinity DataIC50:  2.74nMAssay Description:Mpro activity was measured according to the manufacturer's protocol (BPS Biosciences, cat #78042-2) in 384-well plates. The included recombinant un-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423465(US11753373, Compound A-1-c | WO2006061714, P38.8 |...)
Affinity DataIC50:  14.3nMAssay Description:Mpro activity was measured according to the manufacturer's protocol (BPS Biosciences, cat #78350-2) in 384-well plates. The included recombinant un-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423465(US11753373, Compound A-1-c | WO2006061714, P38.8 |...)
Affinity DataIC50:  20nMAssay Description:The SARS 3CLpro FRET assay measures the protease catalyzed cleavage of TAMRA- SITSAVLQSGFRKMK-(DABCYL)-OH to TAMRA - SITSAVLQ and SGFRKMK- (DABCYL)-O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423465(US11753373, Compound A-1-c | WO2006061714, P38.8 |...)
Affinity DataIC50:  20nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(SARS coronavirus Urbani)
Pfizer

WIPO
LigandPNGBDBM423465(US11753373, Compound A-1-c | WO2006061714, P38.8 |...)
Affinity DataIC50:  2.00E+4nM EC50:  4.20E+6nMAssay Description:Proteolytic activity of Coronavirus 3C protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS 3CI_pro FRET as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423465(US11753373, Compound A-1-c | WO2006061714, P38.8 |...)
Affinity DataEC50:  4.20E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed