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Report error Found 4 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM479502'
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Cleveland Clinic

LigandPNGBDBM479502(ML300-based SC inhibitor 41)
Affinity DataIC50:  19nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479502(ML300-based SC inhibitor 41)
Affinity DataIC50:  68nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479502(ML300-based SC inhibitor 41)
Affinity DataEC50:  500nMAssay Description:Briefly, Vero E6 ACE2 cells were cultured in 96-well flat-bottom plates at a density of 2 104 cells per well. Following infection of the cells with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479502(ML300-based SC inhibitor 41)
Affinity DataEC50:  560nMAssay Description:Confluent monolayers of Vero E6 ACE2 cells in 12-well plates were washed once with DMEM and infected with approximately 50 plaque forming units (PFUs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed