Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with Target = 'Reverse transcriptase/RNaseH' and Ligand = 'BDBM50002692'
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  2nMAssay Description:Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by triplicate assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against HIV1 K103N mutant in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  3nMAssay Description:Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against HIV1 Y188L mutant in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  3nMAssay Description:Effective concentration in vitro against HIV-1-infected CEM cells relative to uninfected untreated controlsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  3nMAssay Description:The compound was evaluated for inhibition of HIV-1 mutant GluL38-Lys recombinant reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 3.10nMAssay Description:Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay in CEM-SS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  8nMAssay Description:Antiviral activity against HIV1 IRLL98 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 10nMAssay Description:Tested for the inhibition towards HIV-reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  10nMAssay Description:Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by reverse transcriptase (RT) assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 11nMAssay Description:antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 17nMAssay Description:Inhibitory concentration against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by triplicate assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 30nMAssay Description:Ability to inhibit the HIV-1 reverse transcriptase in cord blood mononuclear cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  38nMAssay Description:Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 40nMAssay Description:Concentration required to inhibit HIV reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIV-1 reverse transcriptase from peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as inhibition of biotin deoxyuridine triphosphate incorporation into proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataEC50:  2.49E+4nMAssay Description:Tested in vitro against HIV-1 MDR using MAGI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for enzymatic inhibitory activity against recombinant HIV reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant reverse transcriptase (RT) in cell-free Quan-T-RT assay systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50002692(1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-f...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed