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Found 2 Enz. Inhib. hit(s) with Target = 'Smoothened homolog' and Ligand = 'BDBM50394561'
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50394561(CHEMBL2160208)
Affinity DataKi:  37.9nMAssay Description:Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50394561(CHEMBL2160208)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at Smo in mouse Shh-Light 2 cells assessed as inhibition of Shh-induced Gli1-reporter activity after 2 days by dual-luciferase re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed