Report error Found 33 Enz. Inhib. hit(s) with Target = 'Sodium-dependent serotonin transporter' and Ligand = 'BDBM22416'
Affinity DataKd: 0.150nMAssay Description:The potency of the [3H]paroxetine for 5-HT transportersMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 0.130nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of [3H]paroxetine (0.2 nM) binding to 5-HT transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 0.560nMAssay Description:Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serot...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.43nMAssay Description:Inhibition of uptake of [3H]5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.0400nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.0770nMAssay Description:Evaluated for affinity at 5-HT uptake site using [3H]paroxetine as radioligand in radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.0800nMAssay Description:Displacement of [125I]RTI55 binding from human wild type SERTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Displacement of [3H]paroxetine from SERT receptor in human platelet membraneMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.380nMAssay Description:Displacement of [3H]paroxetine from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.420nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Compound was evaluated for its ability to displace [3H]citalopram binding to the rat cortical Serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataKi: 0.730nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
