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Report error Found 4 Enz. Inhib. hit(s) with Target = 'Sphingosine kinase 1' and Ligand = 'BDBM50237417'
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  3nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237417(CHEMBL4077280)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed