Found 27 Enz. Inhib. hit(s) with Target = 'Steroid 17-alpha-hydroxylase/17,20 lyase' and Ligand = 'BDBM25458' TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant CYP17A1 incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Ability to inhibit the C17,20-lyase enzyme by 50% using 17-alpha-hydroxyprogesterone as substrate.More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human progesterone 17-alpha-hydroxylase.More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Ability to inhibit the Steroid 17-alpha-hydroxylase/17,20 lyase enzyme by 50%.More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of C-terminal His-tagged recombinant human CYP17A1delta19H mutant expressed in Escherichia coli DH5alpha assessed as decrease in progester...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of C-terminal His-tagged recombinant human CYP17A1delta19H mutant expressed in Escherichia coli JM109 cells assessed as decrease in proges...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of Szeged
Curated by ChEMBL
University Of Szeged
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of Wistar rat testicular C17,20-lyase using [3H]17-hydroxyprogesterone as substrate preincubated for 20 minsMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of Szeged
Curated by ChEMBL
University Of Szeged
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of Wistar rat testicular C17,20-lyase assessed as androst-4-ene-3,17-dione formation using [3H]17-hydroxyprogesterone as substrate in pres...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of Szeged
Curated by ChEMBL
University Of Szeged
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of CYP17 in Sprague-Dawley rat testes microsomes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pretreated for 5 mi...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 29nMpH: 7.4Assay Description:The inhibition of CYP17A1 by the test compounds was evaluated using a recombinant enzyme. Human CYP17A1 was expressed in E. coli (Ehmer, P. B. et al....More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human CYP17 expressed in human A549 cell membranes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pr...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of CYP17 (unknown origin)More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli coexpressing NADPH-P450 reductaseMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrateMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli co-expressed with NADPH-P450 reductaseMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli using progesterone substrateMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli coexpressing NADPH-P450 reductaseMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli coexpressed with cytochrome P450 reductaseMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli using 1,2[3H]-progesterone as substrate in presence of NADPHMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 72nMpH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Complementary assays were utilized for the quantitative comparison of compound activity data for CYP17A1 and CYP21A2. Progesterone is a substrate for...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of Szeged
Curated by ChEMBL
University Of Szeged
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of Sprague-Dawley rat testicular CYP17More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 17 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
