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Report error Found 6 Enz. Inhib. hit(s) with Target = 'Synaptic vesicular amine transporter' and Ligand = 'BDBM50017701'
TargetSynaptic vesicular amine transporter(Bovine)
Wichita State University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  4nMAssay Description:Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghostsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
Hebrew University of Jerusalem

LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataIC50: 8.30nM Kd:  5.20nMpH: 7.5 T: 2°CAssay Description:Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
Hebrew University of Jerusalem

LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  7.62nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
Hebrew University of Jerusalem

LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
Hebrew University of Jerusalem

LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
Hebrew University of Jerusalem

LigandChemical structure of BindingDB Monomer ID 50017701BDBM50017701(3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-py...)
Affinity DataKi:  54nMAssay Description:Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed