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Found 6 Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50184737'
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  3nMpH: 5.5Assay Description:Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp & Dohme

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity against capsaicin-activated human VR1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50184737(CHEMBL378563 | N-(4-(trifluoromethyl)phenyl)-4-(3-...)
Affinity DataIC50:  26nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed