Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM267873'
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced MIP1betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed