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TargetPyruvate decarboxylase(Zymomonas mobilis subsp. mobilis (strain ATCC 3182...)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50589544(CHEMBL3559521)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of Zymomonas mobilis pyruvate decarboxylase incubated for 3 mins using pyruvate as substrate in presence of TPP by spectrophotometric anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50009575(CHEMBL3234446)
Affinity DataKi:  0.0530nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257221(CHEMBL4059998)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257220(CHEMBL4075830)
Affinity DataKi:  0.120nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257251(CHEMBL4069459)
Affinity DataKi:  0.130nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257228(CHEMBL4077740)
Affinity DataKi:  0.130nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257230(CHEMBL4076754)
Affinity DataKi:  0.140nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257219(CHEMBL4059541)
Affinity DataKi:  0.140nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257252(CHEMBL4076953)
Affinity DataKi:  0.150nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257234(CHEMBL4103607)
Affinity DataKi:  0.170nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257232(CHEMBL4061039)
Affinity DataKi:  0.180nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26236(CHEMBL487569 | N-[6-(3,5-dimethoxyphenyl)-2-(3,5-d...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257229(CHEMBL4098390)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50213021(CHEBI:63621 | Fortovase | Invirase | Ro-31-8959 | ...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human ROCK2 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human ROCK1 expressed in baculovirus expression system by Kinase-Glo luminescent AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26250(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(pyrrolid...)
Affinity DataKi:  0.260nM ΔG°:  -54.2kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50014619(CHEMBL3184840)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315206((R)-2-(6-fluoro-3-(1-(thiazol-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair
TargetType-2 angiotensin II receptor(Pig)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50156173((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]angiotensin 2 from AT2 receptor in pig uterus membrane after 1.5 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50156173((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50156173((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26256(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methox...)
Affinity DataKi:  0.440nM ΔG°:  -52.9kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257231(CHEMBL4065973)
Affinity DataKi:  0.450nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26255(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(3-methox...)
Affinity DataKi:  0.470nM ΔG°:  -52.7kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50199311(CHEMBL215160 | N-butyloxycarbonyl-2-(4-imidazol-1-...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50156167(CHEMBL361927 | butyl (5-isobutylthien-2-yl)sulfony...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26251(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(piperidi...)
Affinity DataKi:  0.560nM ΔG°:  -52.3kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257222(CHEMBL4075655)
Affinity DataKi:  0.560nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50199326(CHEMBL217673 | N-butyloxycarbonyl-2-(4-imidazol-1-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26235(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(2-fluoro-3-...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26249(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(dimethyl...)
Affinity DataKi:  0.610nM ΔG°:  -52.1kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315205((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315205((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26253(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methyl...)
Affinity DataKi:  0.710nM ΔG°:  -51.7kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26254(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-{6-[(2-metho...)
Affinity DataKi:  0.720nM ΔG°:  -51.7kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50088504(A-84538 | ABBOTT-84538 | CHEBI:45409 | Norvir | Ri...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315191((R)-N,N-dimethyl-2-(3-(1-(thiazol-2-yl)ethyl)-1H-i...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315198(2-(6-fluoro-3-((3-methoxypyrazin-2-yl)methyl)-1H-i...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26247(N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[6-(morpholi...)
Affinity DataKi:  0.830nM ΔG°:  -51.3kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM21174(CHEMBL398272 | N-[2-(furan-2-yl)-6-(1,3-thiazol-2-...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Human)
Neurocrine Bioscience

LigandPNGBDBM26234(CHEMBL486950 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  0.920nM ΔG°:  -51.1kJ/molepH: 7.4 T: 22°CAssay Description:The membranes prepared from HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in the pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM108255(US8609833, 86)
Affinity DataKi:  0.970nMAssay Description:Binding affinity to A1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50480942(CHEMBL583069)
Affinity DataKi:  1nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50199331(CHEMBL216250 | N-(1-butyloxy-methylcarbonyl)-3-(4-...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315190((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-1H-inden...)
Affinity DataKi:  1nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Rat)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50257227(CHEMBL4085677)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50480946(CHEMBL583568)
Affinity DataKi:  1.10nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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