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Found 465 with Last Name = 'alimzhanov' and Initial = 'm'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50433602(CHEMBL2381980)
Affinity DataKi:  0.720nMAssay Description:Competitive inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50433601(CHEMBL2381983)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446982(CHEMBL3116050)
Affinity DataIC50: <2nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha'(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446982(CHEMBL3116050)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human CK2alpha2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50433605(CHEMBL2381975)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 (unknown origin) using biotinylated TYK2 peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50433604(CHEMBL2381986)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 (unknown origin) using biotinylated TYK2 peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50433601(CHEMBL2381983)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 (unknown origin) using biotinylated TYK2 peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50433611(CHEMBL2381979)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 (unknown origin) using biotinylated TYK2 peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288372(CHEMBL4173429)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288378(CHEMBL4162065)
Affinity DataIC50: <3nMAssay Description:GRAC: human IMPase 1 inhibitorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288437(CHEMBL4165758)
Affinity DataIC50: <3nMAssay Description:GRAC: human PDE2A selective inhibitorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288438(CHEMBL4173676)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288511(CHEMBL4171692)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288439(CHEMBL4163817)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50288443(CHEMBL4166989)
Affinity DataIC50: <3nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50172329(CHEMBL3809011)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303050((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-metho...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303041((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-5-(5-...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303042((S)-3-(1-(5-fluoropyrimidin-2-yl)ethylamino)-6-met...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303051((S)-5-(5-cyclopropyl-1H-pyrazol-3-ylamino)-3-(1-(5...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303052((S)-N6-(1-(5-fluoropyridin-2-yl)ethyl)-3-methyl-N2...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303053((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-methy...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303054((S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N6-(5-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303054((S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N6-(5-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant JAK2 kinase in presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50313159((S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant JAK2 kinase in presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50343723((S)-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluor...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50335202(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50335203(CHEMBL1650698 | N4-(5-Cyclopropyl-1H-pyrazol-3-yl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 using Km ATP concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446995(CHEMBL3116058)
Affinity DataIC50:  3nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446990(CHEMBL3116055)
Affinity DataIC50: <3nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446982(CHEMBL3116050)
Affinity DataIC50: <3nMAssay Description:Inhibition of Jak1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446982(CHEMBL3116050)
Affinity DataIC50: <3nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50446985(CHEMBL3116063)
Affinity DataIC50: <3nMAssay Description:Inhibition of Jak2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50343727((S)-5-chloro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303053((S)-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N6-(5-methy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 using 5 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303044((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-me...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303054((S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N6-(5-met...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50303043((S)-3-(1-(5-fluoropyridin-2-yl)ethylamino)-6-methy...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 using 2 mM ATP as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50172244(CHEMBL3810020)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50172246(CHEMBL3103191)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50437434(CHEMBL2409175)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50172249(CHEMBL3809915)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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