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Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462180(CHEMBL149482)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5-HT1AR expressed in HEK293 cells assessed as increase in calcium flux by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462141(CHEMBL4248491)
Affinity DataEC50:  11nMAssay Description:Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50462158(CHEMBL4239823)
Affinity DataEC50:  28nMAssay Description:Partial agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in cAMP accumulation by chemiluminescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human 5-HT1AR expressed in CHO-K1 cells assessed as increase in calcium flux by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592916(CHEMBL5206486)
Affinity DataEC50:  11nMAssay Description:Activation of human EAAT2 transfected in COS7 cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592918(CHEMBL5187206)
Affinity DataEC50:  20nMAssay Description:Activation of human EAAT2 transfected in COS7 cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592916(CHEMBL5206486)
Affinity DataEC50:  25nMAssay Description:Activation of human EAAT2 transfected in Glial cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetExcitatory amino acid transporter 2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592918(CHEMBL5187206)
Affinity DataEC50:  0.100nMAssay Description:Activation of human EAAT2 transfected in Glial cells assessed as glutamate uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAlbumin(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50592916(CHEMBL5206486)
Affinity DataKd:  1.97E+6nMAssay Description:Binding affinity to human serum albumin assessed as dissociation constant by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424456(CHEMBL2316109)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424457(CHEMBL2316389)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424458(CHEMBL2316388)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424459(CHEMBL2316387)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424460(CHEMBL2316410)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424461(CHEMBL2316409)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424462(CHEMBL2316408)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424463(CHEMBL2316407)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424464(CHEMBL2316406)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424465(CHEMBL2316404)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424466(CHEMBL2316403)
Affinity DataEC50:  79nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424467(CHEMBL2316397)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424468(CHEMBL2316396)
Affinity DataEC50:  81nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424469(CHEMBL2316392)
Affinity DataEC50:  480nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424470(CHEMBL2316391)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424471(CHEMBL2316390)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM21281(WIN55212-2 | CHEMBL188 | (2,3-dihydro-5-methyl-3-(...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424472(CHEMBL2316386)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424473(CHEMBL2316385)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424473(CHEMBL2316385)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424489(CHEMBL2316384)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424474(CHEMBL2316383)
Affinity DataEC50:  87nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424475(CHEMBL2316382)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424476(CHEMBL2316381)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424490(CHEMBL2316380)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424477(CHEMBL2316379)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424478(CHEMBL2316378)
Affinity DataEC50:  2.90nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424491(CHEMBL2316377)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424479(CHEMBL2316376)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50424492(CHEMBL2316110)
Affinity DataEC50:  260nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293S cell membranes after 1 hr by GTPgamma[35S] binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50207312(CHEMBL3954951)
Affinity DataEC50:  408nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50207313(CHEMBL3962969)
Affinity DataEC50:  1.27E+3nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50207314(CHEMBL3971200)
Affinity DataEC50:  238nMAssay Description:Positive allosteric modulation of human recombinant GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells assessed as potentiation of of GABA i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50204739(CHEMBL3897723)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50204687(CHEMBL3903713)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50204746(CHEMBL3915508)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50204743(CHEMBL3906533)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50204688(CHEMBL3900264)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50204731(CHEMBL3979610)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2018
Entry Details Article
PubMed
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