Compile Data Set for Download or QSAR
Report error Found 2029 with Last Name = 'anzini' and Initial = 'm'
TargetInterleukin-2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532281(CHEMBL4515387)
Affinity DataKd:  4.20E+3nMAssay Description:Binding affinity to human IL-2 measured over 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50379281(CHEMBL2011504)
Affinity DataKd:  930nMAssay Description:Binding affinity to human Bcl-xL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532281(CHEMBL4515387)
Affinity DataKd:  4.20E+3nMAssay Description:Binding affinity to human IL-2 measured over 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBcl-2-like protein 1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50379281(CHEMBL2011504)
Affinity DataKd:  930nMAssay Description:Binding affinity to human Bcl-xL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22040(Ro5-4864 | 4' Cl-diazepam | 4 -chlorodiazepam ...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to TSPO receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50378901(CHEMBL1672418)
Affinity DataKd:  10nMAssay Description:Binding affinity to human TSPOMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Human)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054139((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human TSPOMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50409615(CHEMBL5282701)
Affinity DataKd:  3.80nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex mitochondrial membrane incubated for 60 mins by liquid scintillation spectrometer ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50376928(CHEMBL259114)
Affinity DataKd:  10.5nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50376913(CHEMBL259353)
Affinity DataKd:  14.8nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Rabbit)
University of Siena

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataKd:  200nMAssay Description:Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140783(2-Hydroxymethyl-4-phenyl-quinoline-3-carboxylic ac...)
Affinity DataIC50: 0.000100nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140770(2-Aminomethyl-4-phenyl-quinoline-3-carboxylic acid...)
Affinity DataIC50: 0.00170nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140773(2-Bromomethyl-4-phenyl-quinoline-3-carboxylic acid...)
Affinity DataIC50: 0.0100nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140785(2-Methylaminomethyl-4-phenyl-quinoline-3-carboxyli...)
Affinity DataIC50: 0.0110nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50264106(CHEMBL3818875)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human recombinant sEH using 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid as substrate assessed as formation of 14,15-dihydroxy-5Z,8Z,11Zei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50264106(CHEMBL3818875)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human recombinant sEH using 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid as substrate assessed as formation of 14,15-dihydroxy-5Z,8Z,11Zei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140786(4-Phenyl-quinoline-3-carboxylic acid (3,5-bis-trif...)
Affinity DataIC50: 0.0300nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140772(2-Methyl-4-phenyl-quinoline-3-carboxylic acid 3,5-...)
Affinity DataIC50: 0.0750nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50418331(SPERGUALIN)
Affinity DataIC50: 0.0794nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVasoactive intestinal polypeptide receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50435130(CHEMBL1893324)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity to human VPAC1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355784(CHEMBL1911623)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355785(CHEMBL1911624)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355781(CHEMBL1911620)
Affinity DataIC50: 0.140nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataIC50: 0.140nMAssay Description:Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuropeptide Y receptor type 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50015490(NPY, human, rat | CHEMBL438945 | NPY | H-YPSKPDNPG...)
Affinity DataIC50: 0.190nMAssay Description:Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50140774(2-Dimethylaminomethyl-4-phenyl-quinoline-3-carboxy...)
Affinity DataIC50: 0.220nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355786(CHEMBL1911625)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50519649(CHEMBL4439913)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-P receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50335566(CHEMBL1651026 | Substance P [Sar9,Met(O2)11])
Affinity DataIC50: 0.320nMAssay Description:Binding affinity to human NK1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeurotensin receptor type 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50130880(pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-L...)
Affinity DataIC50: 0.330nMAssay Description:Binding affinity to human NTS1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50355783(CHEMBL1911622)
Affinity DataIC50: 0.340nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50060686(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009718(CHEMBL7550 | 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetraz...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50009718(CHEMBL7550 | 2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetraz...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50060685(9-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]q...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50131724(3-Chloromethyl-4-phenyl-quinoline-2-carboxylic aci...)
Affinity DataIC50: 0.450nMAssay Description:Inhibitory activity against specific binding of [3H]-CB 34 to peripheral benzodiazepine receptor in rat cortical membranes was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM282619(US9884828, 2-114)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM22041(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex membrane incubated for 120 mins by liquid scintillation spectrometer methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcetylcholinesterase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibitory concentration against human acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054126((E)-N-(4-chlorophenyl)-2-(2-(4-chlorophenyl)-1-oxo...)
Affinity DataIC50: 0.620nMAssay Description:Displacement of [3H]PK115 from peripheral benzodiazepine receptor in Sprague-Dawley rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranslocator protein(Rat)
Rottapharm Biotech

Curated by ChEMBL
LigandPNGBDBM50054125(2-[2-(4-Chloro-phenyl)-1-oxo-1,2-dihydro-pyrrolo[3...)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]PK11195 from rat kidney peripheral benzodiazepine receptor (type 1)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGalanin receptor type 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50378616(GALANIN)
Affinity DataIC50: 0.770nMAssay Description:Binding affinity to human GAL1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target2',5'-phosphodiesterase 12(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532283(CHEMBL4556129)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human PDE12 (17 to 609 residues) expresssed in Escherichia coli BL21(DE3) cells using 2-5A as substrate assessed as AMP monomers and AT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target2',5'-phosphodiesterase 12(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50532283(CHEMBL4556129)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human PDE12 (17 to 609 residues) expresssed in Escherichia coli BL21(DE3) cells using 2-5A as substrate assessed as AMP monomers and AT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor B(Rat)
Università

Curated by ChEMBL
LigandPNGBDBM50009712(CHEMBL315104 | 5,7-Dimethyl-2-propyl-3-[2'-(2H-tet...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50620061(CHEMBL5401025)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate preincubated for 30 mins followed by substrate addition and measured after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetType-1 angiotensin II receptor A(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50009712(CHEMBL315104 | 5,7-Dimethyl-2-propyl-3-[2'-(2H-tet...)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 2029 total ) | Next | Last >>
Jump to: