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TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175969(US9688695, 2 | US10047103, 2 | US9605024, Example ...)
Affinity DataEC50:  0.420nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175970(US9688695, 3 | US10047103, 3 | US9605024, Example ...)
Affinity DataEC50:  0.320nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175975(US9688695, 8 | US10047103, 8 | US9605024, Example ...)
Affinity DataEC50:  3.90nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175976(US9688695, 9 | US10047103, 9 | US9605024, Example ...)
Affinity DataEC50:  5.30nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175977(US9688695, 10 | US10047103, 10 | US9605024, Exampl...)
Affinity DataEC50:  3.5nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175985(US9688695, 18 | US10047103, 18 | US9605024, Exampl...)
Affinity DataEC50:  2.5nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM175995(US9688695, 28 | US10047103, 75 | US9688695, 75 | U...)
Affinity DataEC50:  0.510nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176000(US9688695, 33 | US10047103, 33 | US9605024, Exampl...)
Affinity DataEC50:  1.70nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetProteinase-activated receptor 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176146(US9688695, 179 | US10047103, 179 | US9605024, Exam...)
Affinity DataEC50:  1nMAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetHeat shock protein 75 kDa, mitochondrial(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50274535(CHEMBL4126250)
Affinity DataKd:  10nMAssay Description:Inhibition of FITC-geldanamycin binding to recombinant human N-terminal His6-tagged TRAP1 (60 to 704 residues) expressed in Escherichia coli BL21-Cod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50274535(CHEMBL4126250)
Affinity DataKd:  1.5nMAssay Description:Inhibition of FITC-geldanamycin binding to recombinant human HSP90alpha expressed in Escherichia coli by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  1nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50472747(CHEMBL414767)
Affinity DataEC50:  0.759nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataEC50:  0.100nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.437nMAssay Description:Inhibition of electrically evoked contraction of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  0.115nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475329(CHEMBL263588)
Affinity DataEC50:  0.479nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Guinea pig)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  1nMAssay Description:Inhibition of electrically evoked contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataEC50:  0.759nMAssay Description:Inhibition of electrically evoked contraction of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Guinea pig)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of electrically evoked contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475330(CHEMBL442297)
Affinity DataEC50:  1nMAssay Description:Inhibition of electrically evoked contraction of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  5.40nMAssay Description:Inhibition of electrically evoked contraction of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475331(CHEMBL411649)
Affinity DataEC50:  4.90nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475327(CHEMBL410653)
Affinity DataEC50:  0.141nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475329(CHEMBL263588)
Affinity DataEC50:  0.813nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475330(CHEMBL442297)
Affinity DataEC50:  0.302nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Guinea pig)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of electrically evoked contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475331(CHEMBL411649)
Affinity DataEC50:  0.407nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing human NOP receptor (CHOhNOP) More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475325(CHEMBL262544)
Affinity DataEC50:  0.933nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  0.0661nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475325(CHEMBL262544)
Affinity DataEC50:  0.240nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475332(CHEMBL413944)
Affinity DataEC50:  5.90nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  2.60nMAssay Description:Inhibition of electrically evoked contraction of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  0.309nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475332(CHEMBL413944)
Affinity DataEC50:  55nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.0759nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Guinea pig)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475333(CHEMBL264846)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of electrically evoked contraction of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475328(CHEMBL414782)
Affinity DataEC50:  0.0676nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50472747(CHEMBL414767)
Affinity DataEC50:  5.20nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50475330(CHEMBL442297)
Affinity DataEC50:  0.209nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477880(CHEMBL430024)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477881(CHEMBL2372117)
Affinity DataEC50:  11nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477882(CHEMBL413849)
Affinity DataEC50:  4.20nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477883(CHEMBL400369)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477884(CHEMBL267034)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477885(CHEMBL252537)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477886(CHEMBL409555)
Affinity DataEC50:  15nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477887(CHEMBL437389)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477888(CHEMBL411571)
Affinity DataEC50:  34nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetNeuropeptide S receptor(Mouse)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50477889([2Nal2]hNPS)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
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