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TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at room temperature by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  8.10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.490nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195695(CHEMBL3941037)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 37 degC by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 4 degC by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101846((3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3...)
Affinity DataEC50:  4.80nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101837({3-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-4-o-...)
Affinity DataEC50:  420nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101849(3-{2-[(S)-(R)-3-Hydroxy-2-((1S,2R)-3-hydroxy-oct-1...)
Affinity DataEC50:  170nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101835([3-((1R,2S,3R)-3-Hydroxy-2-{(E)-(S)-3-hydroxy-4-[3...)
Affinity DataEC50:  44nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101847({3-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-4-m-...)
Affinity DataEC50:  2.80nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101850({3-[(S)-(R)-3-Hydroxy-2-((1S,2R)-3-hydroxy-oct-1-e...)
Affinity DataEC50:  7.70nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101852((3-{(1R,2S,3R)-2-[(E)-(S)-4-(3-Ethoxymethyl-phenyl...)
Affinity DataEC50:  2.5nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101851((3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3...)
Affinity DataEC50:  3.10nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101842({3-[(S)-(R)-3-Hydroxy-2-((1S,2R)-3-hydroxy-oct-1-e...)
Affinity DataEC50:  4.30nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101840({2-[(S)-(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1-e...)
Affinity DataEC50:  7.80E+3nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101836(6-[(S)-(R)-3-Hydroxy-2-((1S,2R)-3-hydroxy-oct-1-en...)
Affinity DataEC50:  3.70nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101838((3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(4...)
Affinity DataEC50:  32nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101841((3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(2...)
Affinity DataEC50:  580nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101845([3-((1R,2S,3R)-3-Hydroxy-2-{(E)-(S)-3-hydroxy-4-[3...)
Affinity DataEC50:  12nMAssay Description:Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101853((13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-...)
Affinity DataEC50:  2.5nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101839((3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3...)
Affinity DataEC50:  10nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101844((3-{(1R,2S,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3...)
Affinity DataEC50:  37nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101854({3-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-4-p-...)
Affinity DataEC50:  270nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101843({3-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-4-ph...)
Affinity DataEC50:  34nMAssay Description:Evaluated for its competitive binding affinity towards mouse Prostanoid EP4 receptor in CHO cells expressing prostanoid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101836(6-[(S)-(R)-3-Hydroxy-2-((1S,2R)-3-hydroxy-oct-1-en...)
Affinity DataEC50:  3.70nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101853((13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-...)
Affinity DataEC50:  2.5nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101853((13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-...)
Affinity DataEC50:  2.5nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101859(4-(2-{(1R,2R,3R,5R)-5-Fluoro-3-hydroxy-2-[(E)-(S)-...)
Affinity DataEC50:  270nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101863(3-{(S)-3-[(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101855(7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)-3-h...)
Affinity DataEC50:  160nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101857((E)-7-{(1R,2R,3R,5R)-5-Fluoro-3-hydroxy-2-[(E)-(S)...)
Affinity DataEC50:  14nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101858(4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3...)
Affinity DataEC50:  1.60nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101861(4-{(S)-2-[(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1...)
Affinity DataEC50:  3.60nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101862(5-[(S)-(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1-en...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101865((E)-7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)...)
Affinity DataEC50:  44nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101860({(S)-4-[(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1-e...)
Affinity DataEC50:  46nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101864(4-(2-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-...)
Affinity DataEC50:  20nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50101856((E)-7-{(1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-[(E)-(S)...)
Affinity DataEC50:  3.30nMAssay Description:Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50315967(N-(3,4-difluorophenylsulfonyl)-3-(2-(2-(naphthalen...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM578769(US11479550, Example 11-15(2) | US11479550, Example...)
Affinity DataIC50: 0.570nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin E2 receptor EP4 subtype(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM578749(US11479550, Example 3-9(2))
Affinity DataIC50: 0.700nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProstaglandin E2 receptor EP4 subtype(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM578774(US11479550, Example 13 | 4-[2-({2-[3-methyl-6-(met...)
Affinity DataIC50: 0.790nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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