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TargetPeroxisome proliferator-activated receptor gamma(Human)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28759(CHEMBL191275 | (2S)-3-phenyl-2-(4-phenylphenoxy)pr...)
Affinity DataEC50:  480nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28760((2R)-3-phenyl-2-(4-phenylphenoxy)propanoic acid | ...)
Affinity DataEC50:  5.93E+3nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28681(cid_5281055 | [3H]rosiglitazone | CHEMBL121 | ROSI...)
Affinity DataEC50:  40nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28759(CHEMBL191275 | (2S)-3-phenyl-2-(4-phenylphenoxy)pr...)
Affinity DataEC50:  220nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DataEC50:  1.62E+3nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28759(CHEMBL191275 | (2S)-3-phenyl-2-(4-phenylphenoxy)pr...)
Affinity DataEC50:  260nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM24566(JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro...)
Affinity DataEC50:  40nMAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor alpha(Human)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28760((2R)-3-phenyl-2-(4-phenylphenoxy)propanoic acid | ...)
Affinity DataAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Mouse)
Consiglio Nazionale Delle Ricerche

LigandPNGBDBM28760((2R)-3-phenyl-2-(4-phenylphenoxy)propanoic acid | ...)
Affinity DataAssay Description:The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483539(CHEMBL1688184)
Affinity DataEC50:  30nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483540(CHEMBL1688186)
Affinity DataEC50:  190nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483541(CHEMBL1688187)
Affinity DataEC50:  460nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483542(CHEMBL1688190)
Affinity DataEC50:  390nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483543(CHEMBL1688191)
Affinity DataEC50:  340nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483544(CHEMBL1688192)
Affinity DataEC50:  6.24E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483545(CHEMBL1688194)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483546(CHEMBL1688195)
Affinity DataEC50:  2.65E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483539(CHEMBL1688184)
Affinity DataEC50:  60nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483541(CHEMBL1688187)
Affinity DataEC50:  430nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483547(CHEMBL1688189)
Affinity DataEC50:  720nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483542(CHEMBL1688190)
Affinity DataEC50:  280nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483544(CHEMBL1688192)
Affinity DataEC50:  3.27E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483545(CHEMBL1688194)
Affinity DataEC50:  1.53E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483547(CHEMBL1688189)
Affinity DataEC50:  500nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483540(CHEMBL1688186)
Affinity DataEC50:  150nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483546(CHEMBL1688195)
Affinity DataEC50:  2.95E+3nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483548(CHEMBL1688185)
Affinity DataEC50:  200nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483549(CHEMBL1688188)
Affinity DataEC50:  840nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483550(CHEMBL1688183)
Affinity DataEC50:  90nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483549(CHEMBL1688188)
Affinity DataEC50:  860nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483543(CHEMBL1688191)
Affinity DataEC50:  360nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483550(CHEMBL1688183)
Affinity DataEC50:  30nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483548(CHEMBL1688185)
Affinity DataEC50:  320nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483551(CHEMBL1688193)
Affinity DataEC50:  530nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50483551(CHEMBL1688193)
Affinity DataEC50:  380nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372440(CHEMBL260957)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372442(CHEMBL260740)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372441(CHEMBL260958)
Affinity DataEC50:  2.50E+4nMAssay Description:Inhibition of human HDAC1 assessed as histone H4 acetylation in cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372452(CHEMBL409847)
Affinity DataIC50: 1nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Mouse)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse liver HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372470(CHEMBL403323)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372470(CHEMBL403323)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Via Zambeletti 25

Curated by ChEMBL
LigandPNGBDBM50208043(1-methyl-3-(R)-[4,4-Bis-(4-fluoro-phenyl)-2-oxo-im...)
Affinity DataIC50: 4.5nMAssay Description:Activity at muscarinic M3 receptor in Albino Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Via Zambeletti 25

Curated by ChEMBL
LigandPNGBDBM50208035(1-methyl-3-(R)-3-[4,4-bis-(4-fluoro-phenyl)-2-oxo-...)
Affinity DataIC50: 7.60nMAssay Description:Activity at muscarinic M3 receptor in Albino Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Via Zambeletti 25

Curated by ChEMBL
LigandPNGBDBM50208029(1-methyl-3-(R)-3-[4,4-bis-(4-fluoro-phenyl)-2-oxo-...)
Affinity DataIC50: 7.80nMAssay Description:Activity at muscarinic M3 receptor in Albino Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol-induced contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterleukin-8(Human)
Grupo Uriach

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetInterleukin-8(Human)
Grupo Uriach

Curated by ChEMBL
LigandPNGBDBM50295276(2-(2-(2-fluorophenylamino)phenyl)acetic acid | CHE...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Menarini Ricerche

Curated by ChEMBL
LigandPNGBDBM50372451(CHEMBL270739)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInterleukin-8(Human)
Grupo Uriach

Curated by ChEMBL
LigandPNGBDBM50295266(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanoic a...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
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