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TargetGag-Pol polyprotein [588-1027](HIV-1)
Roche Palo Alto

LigandPNGBDBM27616(3-chloro-5-(6-chloro-2-fluoro-3-{1H-pyrazolo[3,4-c...)
Affinity DataEC50:  1nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027](HIV-1)
Roche Palo Alto

LigandPNGBDBM27617(5-(6-bromo-2-fluoro-3-{1H-pyrazolo[3,4-c]pyridazin...)
Affinity DataEC50:  1nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027](HIV-1)
Roche Palo Alto

LigandPNGBDBM27618(3-(2-bromo-4-{1H-pyrazolo[3,4-c]pyridazin-3-ylmeth...)
Affinity DataEC50:  17nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C](Human immunodeficiency virus type 1)
Roche Palo Alto

LigandPNGBDBM27612(3-(6-bromo-2-fluoro-3-{1H-pyrazolo[3,4-b]pyridin-3...)
Affinity DataEC50:  12nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C](Human immunodeficiency virus type 1)
Roche Palo Alto

LigandPNGBDBM27616(3-chloro-5-(6-chloro-2-fluoro-3-{1H-pyrazolo[3,4-c...)
Affinity DataEC50:  5nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C](Human immunodeficiency virus type 1)
Roche Palo Alto

LigandPNGBDBM27617(5-(6-bromo-2-fluoro-3-{1H-pyrazolo[3,4-c]pyridazin...)
Affinity DataEC50:  3nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C](Human immunodeficiency virus type 1)
Roche Palo Alto

LigandPNGBDBM27618(3-(2-bromo-4-{1H-pyrazolo[3,4-c]pyridazin-3-ylmeth...)
Affinity DataEC50: >100nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2009
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  1.10E+3nMAssay Description:The antiviral activity of compounds was examined by evaluating the cytopathic effect in Vero-E6 cells grown at 37°C in a 5% CO2 atmosphere for 72 h u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  770nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448349(Perampanel, 5)
Affinity DataEC50:  2.50E+3nMAssay Description:The antiviral activity of compounds was examined by evaluating the cytopathic effect in Vero-E6 cells grown at 37°C in a 5% CO2 atmosphere for 72 h u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448349(Perampanel, 5)
Affinity DataEC50:  1.50E+3nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448361(Perampanel, 14)
Affinity DataEC50:  3.20E+3nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448369(Perampanel, 21)
Affinity DataEC50:  1.13E+4nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448371(Perampanel, 23)
Affinity DataEC50:  840nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448374(Perampanel, 26)
Affinity DataEC50:  2.00E+3nMAssay Description:The antiviral activity of compounds was examined by evaluating the cytopathic effect in Vero-E6 cells grown at 37°C in a 5% CO2 atmosphere for 72 h u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448374(Perampanel, 26)
Affinity DataEC50:  980nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448375(Perampanel, 27)
Affinity DataEC50:  1.10E+3nMAssay Description:The antiviral activity of compounds was examined by evaluating the cytopathic effect in Vero-E6 cells grown at 37°C in a 5% CO2 atmosphere for 72 h u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  590nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  770nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.51E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.50E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476978(Inhibitor 3 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.76E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476978(Inhibitor 3 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  980nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476981(Inhibitor 4 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.20E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476981(Inhibitor 4 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.10E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476988(Inhibitor 9 of SARS-CoV-2 Mpro)
Affinity DataEC50:  730nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476988(Inhibitor 9 of SARS-CoV-2 Mpro)
Affinity DataEC50:  1.70E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476993(Inhibitor 13 of SARS-CoV-2 Mpro)
Affinity DataEC50: >4.00E+4nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM484208(Inhibitor 16 of SARS-CoV-2 Mpro)
Affinity DataEC50:  530nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM484208(Inhibitor 16 of SARS-CoV-2 Mpro)
Affinity DataEC50:  1.20E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM484209(Inhibitor 17 of SARS-CoV-2 Mpro)
Affinity DataEC50:  820nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476998(Inhibitor 18 of SARS-CoV-2 Mpro | US20240092759, C...)
Affinity DataEC50:  3.20E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476998(Inhibitor 18 of SARS-CoV-2 Mpro | US20240092759, C...)
Affinity DataEC50:  1.00E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476999(Inhibitor 19 of SARS-CoV-2 Mpro)
Affinity DataEC50:  175nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476999(Inhibitor 19 of SARS-CoV-2 Mpro)
Affinity DataEC50:  80nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM484213(Inhibitor 21 of SARS-CoV-2 Mpro)
Affinity DataEC50:  1.08E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252092(CHEMBL4082756)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252099(CHEMBL4087237)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252092(CHEMBL4082756)
Affinity DataEC50:  71nMAssay Description:Agonist activity at mouse GPR52More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252102(CHEMBL4059658)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252136(CHEMBL4064577)
Affinity DataEC50:  210nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252137(CHEMBL4074656)
Affinity DataEC50:  3.90E+3nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252138(CHEMBL4095110)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252139(CHEMBL4091718)
Affinity DataEC50:  690nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252140(CHEMBL4081439)
Affinity DataEC50:  160nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252141(CHEMBL4099457)
Affinity DataEC50:  400nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252151(CHEMBL4073584)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252152(CHEMBL4062229)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252186(CHEMBL4072782)
Affinity DataEC50:  370nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
TargetG-protein coupled receptor 52(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50252187(CHEMBL4099668)
Affinity DataEC50:  83nMAssay Description:Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2019
Entry Details Article
PubMed
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