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TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50067536(5-Hydroxy-2,4-dimethyl-8-[2'-(1H-tetrazol-5-yl)-bi...)
Affinity DataIC50:  0.170nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50471877(CHEMBL135574)
Affinity DataIC50:  0.410nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  1.20nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087670(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-methy...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087664(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-dimet...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087675(Biphenyl-2-carboxylic acid [4-(3-[1,4']bipiperidin...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50471878(CHEMBL337067)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087674(Biphenyl-2-carboxylic acid [3-chloro-4-(3-{[(2-dim...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087667(10-{4-[(Biphenyl-2-carbonyl)-amino]-2-chloro-benzo...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087672(Biphenyl-2-carboxylic acid [4-(3-dimethylaminometh...)
Affinity DataIC50:  5.20nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50471879(CHEMBL135309)
Affinity DataIC50:  6.5nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087673(Biphenyl-2-carboxylic acid {3-methoxy-4-[3-(4-meth...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087666(Biphenyl-2-carboxylic acid [3-chloro-4-(3-dimethyl...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087665(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-dimet...)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50222059(CHEMBL392363 | N-[3-chloro-4-(3-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087669(Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-methy...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087668(10-[2-Chloro-4-(5-fluoro-2-methyl-benzoylamino)-be...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50087671(Biphenyl-2-carboxylic acid [4-(3-dimethylaminometh...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50222058(CHEMBL237772 | N-[3-chloro-4-(3-oxo-11,11a-dihydro...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of aldose reductase from the partially purified bovine lensMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50177593((5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  80.3nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  124nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50016901((2-Methyl-3-oxo-3H-phenalen-1-yl)-acetic acid | CH...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177593((5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  353nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  519nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of aldose reductase (or polyol accumulation) in isolated rat sciatic nerve by compound at 10e-5 M concentrationMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50016902(CHEMBL168106 | [Methyl-(naphthalene-1-carbothioyl)...)
Affinity DataIC50:  730nMAssay Description:In vitro inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026173(2-{4-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-ethyl]-pi...)
Affinity DataIC50:  760nMAssay Description:Compound was for its ability to displace [3H]-haloperidol binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177593((5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  778nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026171(2-[4-(2-Hydroxy-2-phenyl-ethyl)-piperazin-1-yl]-cy...)
Affinity DataIC50:  880nMAssay Description:Compound was for its ability to displace [3H]-haloperidol binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222060(1-(2-(2-chloro-4-(5-fluoro-2-methylbenzamido)benza...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222059(CHEMBL392363 | N-[3-chloro-4-(3-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222060(1-(2-(2-chloro-4-(5-fluoro-2-methylbenzamido)benza...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222059(CHEMBL392363 | N-[3-chloro-4-(3-oxo-2,3-dihydro-1H...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50222057(2-(2-chloro-4-(5-fluoro-2-methylbenzamido)benzamid...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222057(2-(2-chloro-4-(5-fluoro-2-methylbenzamido)benzamid...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222058(CHEMBL237772 | N-[3-chloro-4-(3-oxo-11,11a-dihydro...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222057(2-(2-chloro-4-(5-fluoro-2-methylbenzamido)benzamid...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50222058(CHEMBL237772 | N-[3-chloro-4-(3-oxo-11,11a-dihydro...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50222060(1-(2-(2-chloro-4-(5-fluoro-2-methylbenzamido)benza...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026172(2-{4-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-...)
Affinity DataIC50:  1.05E+3nMAssay Description:Compound was for its ability to displace [3H]-haloperidol binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50452265(CHEMBL2115477)
Affinity DataIC50:  1.07E+3nMAssay Description:Compound was for its ability to displace [3H]-haloperidol binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50452267(Ciladopa)
Affinity DataIC50:  1.09E+3nMAssay Description:Ability to displace [3H]WB-4101 from rat brain alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Affinity DataIC50:  1.20E+3nMAssay Description:Compound was for its ability to displace [3H]-haloperidol binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50222061(10-[2-chloro-4-(3-methyl-pyrazol-1-yl)-benzoyl]-1,...)
Affinity DataIC50:  1.21E+3nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50452266(CHEMBL2115071)
Affinity DataIC50:  1.44E+3nMAssay Description:Ability to displace [3H]WB-4101 from rat brain alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50452265(CHEMBL2115477)
Affinity DataIC50:  1.50E+3nMAssay Description:Compound was for its ability to displace [3H]-haloperidol binding to rat striatal Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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